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Localization of active cell proliferation in the Adjacent Zone: On day 3 after burn, increased IHC staining of pimonidazole did not correlate with the cellular proliferation markers Ki67. The area of active proliferation was in the Adjacent Zone (in blue), not the Leading Zone (in red). Multiple layers of proliferating cells were seen in the Adjacent Zone, while in the Leading Zone, as in normal skin, just a single layer of proliferating cells were found.
