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Localization of markers for cell growth (K17) and migration (E-cadherin) with HIF-1α in the leading zone: Increased staining for K17, a marker of cellular growth, co-localized with increased HIF-1α density in the leading zone. Conversely, staining for E-cadherin was decreased in the same region. E-cadherin is down-regulated in regions of active cellular migration.
