Table 1.
Gender, day-care attendance and outcomes by TLR2/−16934 genotype.
| Variable | Whole group Frequency (%) | AA Frequency (%) | AT+TT Frequency (%) | p-value* |
|---|---|---|---|---|
| MAAS | ||||
| Population (n=727) | 160 (22.0) | 567 (78.0) | ||
| Male | 386/727 (53.1) | 78/160 (48.8) | 308/567 (54.3) | 0.21 |
| Attended day-care | 504/727 (69.3) | 109/160 (68.1) | 395/567 (69.7) | 0.71 |
| Sensitization (IgE) | ||||
| Age 3 years | 29/129 (22.5) | 5/27 (18.5) | 24/101 (23.5) | 0.58 |
| Age 5 years | 116/416 (27.9) | 30/96 (31.3) | 86/320 (26.9) | 0.40 |
| Age 8 years | 167/414 (40.3) | 40/88 (45.5) | 127/326 (39.0) | 0.27 |
| Sensitization (SPT) | ||||
| Age 3 years | 135/646 (20.9) | 33/145 (22.8) | 93/501 (20.4) | 0.53 |
| Age 5 years | 165/648 (25.5) | 34/142 (23.9) | 131/506 (25.9) | 0.64 |
| Age 8 years | 192/657 (29.2) | 34/144 (23.6) | 158/513 (30.8) | 0.09 |
| Age 11 years | 177/563 (31.4) | 38/122 (31.2) | 139/441 (31.5) | 0.94 |
| Atopic wheeze (IgE) | ||||
| Age 3 years | 11/128 (8.6) | 2/27 (7.4) | 9/101 (8.9) | 1.00 |
| Age 5 years | 31/412 (7.5) | 9/96 (9.4) | 22/316 (7.0) | 0.51 |
| Age 8 years | 53/412 (12.9) | 12/87 (13.8) | 41/325 (12.6) | 0.72 |
| Atopic wheeze (SPT) | ||||
| Age 3 years | 38/642 (5.9) | 12/145 (8.3) | 26/497 (5.2) | 0.17 |
| Age 5 years | 48/647 (7.4) | 12/142 (8.5) | 32/505 (7.1) | 0.60 |
| Age 8 years | 69/657 (10.5) | 12/144 (8.3) | 57/513 (11.1) | 0.34 |
| Age 11 years | 57/563 (10.1) | 11/122 (9.0) | 46/441 (10.4) | 0.65 |
| EVH airway hyperreactivity | ||||
| Age 5 years | 73/473 (15.4) | 14/105 (13.3) | 59/368 (16) | 0.50 |
| IIS | ||||
| Population (n = 263) | 70/263 (26.6) | 193/263 (73.4) | ||
| Male | 120/263 (45.6) | 32/70 (45.7) | 88/193 (45.6) | 1.00 |
| Attended day-care | 130/263 (49.4) | 34/70 (48.6) | 96/193 (49.7) | 0.89 |
| Sensitization (IgE) | ||||
| Age 1 year | 26/209 (12.4) | 7/57 (12.3) | 19/152 (12.5) | 1.00 |
| Age 2 years | 39/187 (20.9) | 13/54 (24.1) | 26/133 (19.6) | 0.55 |
| Age 3 years | 57/178 (32.0) | 18/50 (36.0) | 39/128 (30.5) | 0.48 |
| Age 5 years | 62/153 (40.5) | 15/44 (34.1) | 47/109 (43.1) | 0.36 |
| Atopic wheeze (IgE) | ||||
| Age 1 year | 6/205 (2.9) | 2/56 (3.6) | 4/149 (2.7) | 0.67 |
| Age 2 years | 10/181 (5.5) | 3/52 (5.8) | 7/129 (5.4) | 1.00 |
| Age 3 years | 17/175 (9.7) | 5/49 (10.2) | 12/126 (9.5) | 1.00 |
| Age 5 years | 16/146 (11.0) | 4/42 (9.5) | 12/104 (11.5) | 1.00 |
*
Chi-squared test