Inhibition of cPLA2 with AACOCF3 decreases tumor size in irradiated mouse models. Using heterotopic tumor models of A2780 human ovarian carcinoma, nude mice were treated intraperitoneally with vehicle (control) or 10 mg/kg AACOCF3, and tumors were irradiated 30 minutes later with 3 Gy. Treatment was repeated for 5 consecutive days. Tumor volumes were calculated using external caliper measurements. Shown are the mean A2780 tumor volumes in each of the treatment groups (control, IR, AACOCF3, and AACOCF3 + IR) with SEM from group of 5 mice; * p < 0.05.