Table 1.
Demographic, epidemiologic and virologic characteristics of the HIV-1 nontransmission and transmission serodiscordant Zambian couples
| Nontransmission couples | Transmission couples | P | |
|---|---|---|---|
| Characteristic | |||
| Number of couples | 327 | 240 | |
| Male/Female (index partner) | 148/179 | 147/93 | 0.0002 |
| Age of partners (yrs) | |||
| Index | 31.5 ± 7.9 | 30.6 ± 7.8 | 0.170 |
| Exposed | 32.0 ± 8.3 | 28.6 ± 7.3 | < 0.0001 |
| Follow-up time (median [IQR], months) | 31.5 [17.0-56.1] | 17.7 [8.8-36.2] | < 0.0001 |
| Male circumcised | |||
| Index | 8.8% | 9.0% | 0.970 |
| Exposed | 19.5% | 9.9% | 0.053 |
| Genital ulcers | |||
| Index | 12.8% | 36.6% | < 0.0001 |
| Exposed | 4.1% | 26.3% | < 0.0001 |
| Genital inflammation a | |||
| Index | 10.3% | 26.3% | < 0.0001 |
| Exposed | 6.6% | 29.1% | < 0.0001 |
| Any sexually transmitted disease | |||
| Index | 20.7% | 50.2% | < 0.0001 |
| Exposed | 10.0% | 46.0% | < 0.0001 |
| HIV-1 RNA level (log10) in index partner | 4.47 ± 0.90 | 4.96 ± 0.70 | < 0.0001 |
| HIV-1 RNA level (log10) in seroconverted partner | 4.50 ± 0.80 | NA | |
a In the 3-6 months before HIV-1 transmission (transmission couples) or latest follow-up visit (nontransmission couples).