Table 3.
The impact of CCR2-CCR5 haplotypes on HIV-1 viral load in Zambian index partners and seroconverters
| Index partners | Recent seroconverters | |||||
|---|---|---|---|---|---|---|
| (N = 567) | (N = 240) | |||||
| Viral Load Table for CCR5 haplotype/diplotype | ||||||
| Haplotype/diplotype | N | β ± SEa | P* | N | β ± SEa | P* |
| HHF*2 | 232 | -0.21 ± 0.09 | 0.024 | 89 | -0.10 ± 0.58 | 0.089 |
| HHF*2/HHF*2 | 27 | -0.08 ± 0.16 | 0.625 | 10 | -0.70 ± 0.26 | 0.007 |
| HHD (All) | 164 | -0.12 ± 0.06 | 0.052 | 69 | 0.24 ± 0.10 | 0.021 |
| HHE (All) | 131 | 0.13 ± 0.08 | 0.096 | 61 | 0.12 ± 0.12 | 0.339 |
| HHD/HHE | 18 | -0.22 ± 0.20 | 0.270 | 16 | 0.49 ± 0.21 | 0.020 |
| HHD/X (No HHE) | 146 | -0.11 ± 0.08 | 0.157 | 53 | 0.14 ± 0.13 | 0.284 |
| HHE/X (No HHD) | 113 | 0.19 ± 0.09 | 0.026 | 45 | -0.06 ± 0.13 | 0.673 |
| Multivariable Model for Interaction** | ||||||
| Haplotype/diplotype | N | β ± SEa | P* | N | β ± SEa | P* |
| HHD/X (No HHE or HHF*2) | 109 | -0.16 ± 0.09 | 0.560 | 37 | 0.24 ± 0.16 | 0.118 |
| HHE/X (No HHD or HHF*2) | 69 | 0.36 ± 0.11 | 0.002 | 31 | 0.10 ± 0.16 | 0.556 |
| HHD/HHE | 18 | -0.16 ± 0.20 | 0.444 | 16 | 0.54 ± 0.22 | 0.014 |
| HHF*2/HHF*2 | 27 | -0.02 ± 0.16 | 0.918 | 10 | -0.58 ± 0.26 | 0.027 |
| HHF2/X (No HHD, HHE or HHF*2) | 124 | 0.05 ± 0.09 | 0.602 | 49 | 0.10 ± 0.14 | 0.496 |
a SE, standard error of the β estimate according to linear regression models.
* P value adjusted for the sex and age at VL for all the individuals.
** Individuals with HHD/HHF*2, HHE/HHF*2 diplotypes are in the reference group in the multivariable model for interaction.