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. 2011 Apr 12;6(4):e18636. doi: 10.1371/journal.pone.0018636

Figure 4. Pathway diagram showing the hypothetical positions of the GBM survival associated genes MTR and CCNB1 in the glioblastoma p53 pathway [3].

Figure 4

KEGG annotates CCNB1 to belong to the p53 pathway together with CCNB2, CCNB3 and CDC2 [6]. In the KEGG p53 signaling pathway, these are regulated by the genes SFN, GADD45G, GADD45A and GADD45B, which constitute a subset of the p53 target genes. In the KEGG glioma pathway, G2 arrest impairment is annotated as one result of the altered p53 pathway activation [6].