Table 1. Example use cases of CANGES.

CANGES use cases
	Goal	Input	Databases	Result
1.	Create a set of focal genes or central SNPs based on previously found interesting genes.	List of proteins	KEGG, Reactome, PINA, ENSEMBL, Hapmap, PolyPhen, SNPs3D, SIFT	A list of focal genes and their central SNPs with SNP annotations.
2.	Create a set of focal genes or SNPs based on previously found interesting pathways.	List of pathway names	KEGG, Reactome, PINA, ENSEMBL, Hapmap, PolyPhen, SNPs3D, SIFT	A list of focal genes and their central SNPs with SNP annotations.
3.	Get central SNPs for a custom pathway or a set of interesting genes.	List of genes	ENSEMBL, Hapmap, PolyPhen, SNPs3D, SIFT	A list of central SNPs with annotations.
4.	Find predictions for a set of coding SNPs.	List of genes	PolyPhen, SNPs3D, SIFT	A list of functional predictions for coding SNPs.

The modular structure of CANGES enables selecting inputs, outputs to serve various research goals.