Fig. 5.
Summary of behavioral results. Behavioral results are reanalyzed from data previously published by Escanilla et al. (2010) and Mandairon et al. (2006b). A: rats with cannulas for drug infusions in both MOBs were tested on odor detection and discrimination using a habituation ask. Odors were presented in the home cage using a weighing dish with odor impregnated filter paper. B: rats were first habituated to the behavioral context by 3 successive presentations of mineral only (MO). Odor detection was then tested by presenting a novel odorant (O1; detection). After 3 habituation trials to this odorant, discrimination was tested by a single presentation of a second, chemically and perceptually similar odorant (O2). C and D: behavioral results. Rats were originally tested at a range of odor concentrations with vapor partial pressures varying from 10−2 to 10−6 Pa. Data presented pertain to the lowest concentration used only. Rats were infused with a range of NE concentrations as shown. C: odor detection magnitude at the lowest odor concentration tested (10−6 Pa) as a function of NE concentration. Detection magnitude is calculated as (O1 − H4)/(O1 + H4), where O1 is the first response to the novel odor and H4 is the response during the last habituation trial to mineral oil. This index varies between 0 (O1 = H4, no detection) and 1 (O1 >> H4, high detection) and is normalized with respect to individual differences in sniff times. Note that detection magnitude follows a nonmonotonic function of NE concentration, as would be predicted by the nonmonotonic dependency of cellular modulation by NE. D: odor discrimination magnitude at the lowest odor concentration tested (10−6 Pa) as a function of NE concentration. Discrimination magnitude is calculated as (O2 − O1)/(O2 + O1), where O2 is the response to the second odor and O1 is the response during the last trial with O1. The index varies between 0 (O2 = O1, no discrimination) and 1 (O2 >> O1, high discrimination) and is normalized with respect to individual sniff times.