Table 4.

Relation of LEE to Hepatitis Status and CD4+ T-Cell Count Changes

Progression to LEE	HBV and/or HCV Status	Number of Patients	Number of Measurements	Baseline Median HIV RNA PCR	CD4 Intercept (SE)	Mean CD4 Slope (SE)	Mean CD4 at 2 Months (95% CI)	P Value
Yes	Infected	36	53	161,105	98 (19)	99 (17)	295 (230,361)	–
No	Infected	34	60	135,660	136 (20)	62 (16)	260 (197,321)	0.11
Yes	Uninfected	24	37	152,080	100 (23)	36 (19)	171 (92,250)	0.01
No	Uninfected	183	283	173,390	100 (9)	59 (7)	217 (191,244)	0.03

Mean CD4 T-cell counts (cells/μL) in ARV-naïve HIV-infected patients are given. Mean rate (mean slope) of increase of CD4 T-cell counts in the first 2 months of follow-up and the mean CD4 cells count at 2 months for HIV-infected subjects with HBV/HCV infected status who developed LEE or did not develop LEE and HIV-infected subjects with HBV/HCV uninfected status who developed LEE or did not develop LEE. CD4 T-cell counts were excluded after the diagnosis of LEE. Analyses included 277 patients (433 CD4 T-cell measurements) and 60 developed LEE subsequent to initiation of ARV therapy (median time until LEE diagnosed = 83 days).