Table 3.

Published Risk Scoring Systems for IVIG Resistance for Japanese Subjects

Score Component	Point Assignment
KOBAYASHI (7 variables)
N=112 Resistant, N=434 Responsive
Low risk: 0–3; High Risk: ≥ 4
Sensitivity: 86%; Specificity: 67%;
PPV: 43%; NPV: 95%
AST ≥ 100	2
Sodium < 133 mmol/L	2
Fever Days ≤ 4	2
%Neutrophils ≥ 80	2
C-Reaction protein ≥ 10 mg/dL	1
Age ≤ 1 year	1
Plaletets ≤ 30 × 104/mm3	1
EGAMI (5 variables)
N=41 Resistant, N=279 Responsive
Low Risk: 0–2; High Risk: ≥ 3
Sensitivity: 78%; Specificity: 76%;
PPV: 32%; NPV: 96%
ALT ≥ 80	2
Fever Days ≤ 4	1
C-Reactive protein ≥ 8 mg/dL	1
Age < 6 months	1
Plaletets ≤ 30 × 104/mm3	1
SANO (3 variables)
N=22 Resistant, N=90 Responsive
Low Risk: 0–1; High Risk=2
Sensitivity: 77%; Specificity: 86%;
PPV: 59%; NPV: 94%
AST ≥ 200	1
Total Bilirubin ≥ 0.9 mg/dL	1
C-Reactive protein ≥ 7 mg/dL	1

ALT=Alanine aminotransferase

AST=Aspartate aminotransferase

PPV=Positive predictive value

NPV=Negative predictive value