Table 3. Analysis of the haplotypes grouped by the allele at each SNP.
The promoter activities (β-galactosidase normalized luciferase activity) of different haplotypes were grouped by the alleles of four SNPs; the other three SNPs could not be compared as there was only one representative haplotype for one of the alleles. The ratio of the activity of the two groups was determined and the significance of this ratio was calculated by t-test.
| Allele 1 | Allele 2 | Ratio of allele 1/allele 2 | p-value | |
|---|---|---|---|---|
| rs1229982 | A | C | 1.39 | 6.2×10−6 |
| rs6810842 | C | A | 0.95 | 0.46 |
| rs2070897 | C | T | 0.94 | 0.42 |
| rs1159918 | T | G | 0.94 | 0.42 |