TABLE 4. Comparison of area under the time-course curves for enrichment of n-3 and n-6 HUFAs.

Tissues	Fatty Acids	AUC0→600h (mol/mol%×h)
		Control Diet	DHA Diet
Plasma	20:5n-3	618.1 ± 39.5	281.4 ± 23.3	***
	22:5n-3	735.7 ± 28.7	325.8 ± 21.8	***
	22:6n-3	408.1 ± 28.0	92.5 ± 6.0	***
	20:3n-6	175.5 ± 5.7	156.8 ± 16.6
	20:4n-6	81.2 ± 7.9	71.1 ± 6.9
	22:4n-6	103.3 ± 5.5	94.7 ± 8.3
	22:5n-6	61.2 ± 4.4	35.2 ± 6.7	*
Liver	20:5n-3	350.9 ± 16.9	168.7 ± 18.8	***
	22:5n-3	364.1 ± 29.4	189.1 ± 17.5	**
	22:6n-3	234.2 ± 12.0	60.2 ± 5.0	***
	20:3n-6	79.4 ± 11.1	70.6 ± 8.5
	20:4n-6	51.8 ± 3.1	46.6 ± 1.8
	22:4n-6	56.4 ± 5.9	56.3 ± 5.5
	22:5n-6	32.7 ± 2.4	24.4 ± 4.0
Heart	20:5n-3	538.4 ± 64.8	265.3 ± 4.6	**
	22:5n-3	600.1 ± 92.1	330.5 ± 19.5	*
	22:6n-3	387.8 ± 49.3	87.9 ± 10.6	***
	20:3n-6	146.4 ± 20.5	142.8 ± 10.3
	20:4n-6	62.2 ± 6.2	56.8 ± 0.5
	22:4n-6	90.2 ± 11.1	82.2 ± 2.4
	22:5n-6	28.3 ± 8.7	8.0 ± 1.0	NA
Brain	20:5n-3	189.6 ± 26.8	105.5 ± 6.9	*
	22:5n-3	378.6 ± 24.7	221.9 ± 21.2	**
	22:6n-3	104.0 ± 9.6	32.8 ± 4.0	***
	20:3n-6	75.2 ± 2.4	75.0 ± 4.5
	20:4n-6	38.9 ± 1.4	31.7 ± 1.2	**
	22:4n-6	34.0 ± 1.5	26.9 ± 1.2	**
	22:5n-6	9.6 ± 0.7	5.2 ± 1.1	*

AUC values were presented as mean ± SEM (n=4).

Two-tailed, unpaired t-test determined the significant difference between diet groups at P value of 0.05*, 0.01**, 0.001 or lower ***.

NA indicates not available.