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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2011 Feb 24;50(5):841–848. doi: 10.1016/j.yjmcc.2011.02.003

Figure 1. Schematic description of in vivo phage display screen in a rat model of ischemia-reperfusion.

Figure 1

In the first round of biopanning, a phage library displaying random peptides is injected into a rat, and phage homing to various tissues are recovered for various assays. Phage recovered from ischemic heart tissue are amplified and used for the next round of biopanning. Three to four rounds of biopanning typically lead to enrichment of phage-peptide clones with high specificity of homing.