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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2011 Feb 24;50(5):841–848. doi: 10.1016/j.yjmcc.2011.02.003

Figure 3. The CSTSMLKAC peptide homes to ischemic myocardium.

Figure 3

Peptide sequences CSTSMLKAC, CKPGTSSYC, and CPDRSVNNC were tested for their homing capability to ischemic left ventricle (LV) as synthetic peptides conjugated with fluorescein in vivo. Peptides were injected into a rat heart with ischemia-reperfusion. The CSTSMLKAC peptide showed significantly higher intensity in the ischemic LV compared to the negative controls: linear form of the peptide (***p<0.001), scrambled peptide with the same amino acids of peptide (**p<0.01), and PBS (*p<0.05) (A). The other two peptide motifs did not show any significant differences compared to the negative controls and the non-ischemic tissue (B and C).