Table 2.
Hemodynamic and echocardiographic assessment of systemic administration of fluorescein- CSTSMLKAC on heart function in rats after ischemia/reperfusion injury.
| PBS | Homing peptide | Scrambled peptide | |
|---|---|---|---|
| Hemodynamic measurement | |||
| Heart rate [beats/min] | 444.8±13.14 | 454.75±13.88 | 430.75±20.59 |
| End-systolic volume [μl] | 309±33.9 | 280.76±15.91 | 260.91±10.99 |
| End-diastolic volume [μl] | 406.1±42.53 | 393.56±25.62 | 362.72±14.82 |
| End-systolic pressure [mmHg] | 107.5±9.2 | 119±3.16 | 120.1±3.48 |
| End-diastolic pressure [mmHg] | 3.87±0.35 | 3.96±0.67 | 3.08±0.22 |
| Stroke volume [μl] | 97.15±14.58 | 112.82±13.61 | 101.81±13.74 |
| Ejection fraction [%] | 23.79±2.79 | 28.44±2.09 | 27.89±3.01 |
| Cardiac output [μl/min] | 42640±5533 | 51430±6708 | 44530±7633 |
| Cardiac index [ml/min per 100 g] | 20.38±2.71 | 19.87±2.54 | 20.96±4.48 |
| Echocardiography | |||
| Anterior wall thickness [mm] | 2.01±0.06 | 2.00±0.04 | 2.08±0.08 |
| Posterior wall thickness [mm] | 1.81±0.09 | 1.73±0.10 | 1.83±0.06 |
| End-systolic dimension [mm] | 3.24±0.20 | 2.49±0.51 | 2.93±0.18 |
| End-diastolic dimension [mm] | 5.36±0.10 | 5.33±0.36 | 5.16±0.23 |
| % Fractional shortening | 39.39±4.35 | 54.05±6.72 | 43.20±3.22 |
| Left ventricle mass [g] | 655±30.24 | 635±84.31 | 646±55.48 |
| LVM/BW | 3.13±0.10 | 2.41±0.23 | 2.94±0.32 |
| Body weight [g] | 209.3±7.36 | 260.25±13.14 | 224±22.01 |