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. Author manuscript; available in PMC: 2011 Dec 22.
Published in final edited form as: J Am Chem Soc. 2010 Nov 24;132(50):17701–17703. doi: 10.1021/ja1089759

Table 3.

One-Pot Palladium-Catalyzed Cross-Coupling Reactions

graphic file with name nihms254590t28.jpg
entry first chloride second chloride product isolated yield (%)
1 graphic file with name nihms254590t29.jpg graphic file with name nihms254590t30.jpg graphic file with name nihms254590t31.jpg 85
2 graphic file with name nihms254590t32.jpg graphic file with name nihms254590t33.jpg graphic file with name nihms254590t34.jpg 90
3 graphic file with name nihms254590t35.jpg graphic file with name nihms254590t36.jpg graphic file with name nihms254590t37.jpg 63
4 graphic file with name nihms254590t38.jpg graphic file with name nihms254590t39.jpg graphic file with name nihms254590t40.jpg 60
5 graphic file with name nihms254590t41.jpg graphic file with name nihms254590t42.jpg graphic file with name nihms254590t43.jpg 55

General conditions: 2.5 mol % of 2, 5 mol % of X-Phos, 2.5 mol % of NaOt-Bu, 3 equiv of KOAc, 3 equiv of 1, EtOH (0.1 M), 80 °C, 2 h. 1 equiv of the second aryl or heteroaryl chloride, 3 equiv of 1.8 M K2CO3, 80 °C, 15 h.