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. Author manuscript; available in PMC: 2011 Dec 21.
Published in final edited form as: Circulation. 2010 Nov 15;122(25):2669–2679. doi: 10.1161/CIRCULATIONAHA.110.982298

Figure 7. Genetic blockade of CaMKII phosphorylation of RyR2 reduces risk for pacing-induced ventricular ectopy.

Figure 7

(A) Representative ECG tracing of pacing-induced non-sustained VT (NSVT) in WT mice 8 weeks after transverse aortic constriction (TAC; top), whereas the S2814A TAC mice typically showed sinus rhythm (bottom). (B) Bar graph showing incidence of pacing-induced NSVT in WT and S2814A mice at 8 weeks post-TAC. (C) Representative Western blots showing total RyR2 and CaMKII-phosphorylated RyR2 at S2814 in WT and S2814A mice at 8 weeks after transverse aortic constriction (TAC). (D) Bar graphs showing averaged ratio between phosphorylated RyR2-pS2814 and total RyR2. (E) Representative Western blots showing total RyR2 and PKA-phosphorylated RyR2 at S2808 in WT and S2814A mice at 8 weeks after TAC. (F) Bar graphs showing averaged ratio between phosphorylated RyR2-pS2808 and total RyR2. N is shown in bar graphs. Fisher’s Exact test was used to compare NSVT incidence; Student’s t-test was used to compare Western blot data. *P<0.05 versus WT surgically matched control.