Table 1.

Echocardiographic parameters of WT and S2814D mice at 3 and 12 months of age.

Age	3 months		12 months		P Values
	WT (n=14)	S2814D (n=14)	WT (n=14)	S2814D (n=14)	3 months	12 months
HR (bpm)	448.1±12.2	455.5±11.0	484.6±12.4	459.6±10.6	0.68	0.13
EF (%)	59.4±0.7	59.1±0.7	56.9±0.7	52.4±1.8	0.87	0.02
FS (%)	31.2±1.1	31.0±0.7	30.3±0.7	27.4±0.9	0.85	0.02
ESD (mm)	2.68±0.10	2.76±0.07	2.85±0.06	3.13±0.09	0.53	0.02
EDD (mm)	3.89±0.09	3.99±0.07	4.09±0.06	4.30±0.08	0.39	0.05
IVSs (mm)	0.90±0.03	0.89±0.03	0.94±0.02	0.95±0.03	0.82	0.58
IVSd (mm)	0.67±0.03	0.67±0.03	0.72±0.03	0.77±0.03	0.93	0.23
LVPWs(mm)	0.99±0.05	0.95±0.03	1.06±0.03	1.13±0.05	0.84	0.20
LVPWd(mm)	0.68±0.05	0.66±0.03	0.73±0.03	0.84±0.04	0.64	0.05

Data are expressed as mean ± SEM. HR = heart rate; bpm = beats per minute; EF = ejection fraction; FS = left ventricular fractional shortening; ESD = end-systolic diameter; EDD = end-diastolic diameter; IVSs/IVSd = intraventricular septal wall thickness in systole/diastole; LVPWs/ LVPWd = left ventricular posterior wall thickness in systole/diastole. Student’s t-test was used to compare intra-group differences; P values between WT and S2814D mice at 3 and at 12 months are displayed to the right.