Table 3. Baseline characteristics of women grouped by AKT1 G205T genotype.
| GG (n = 20-38) |
GT+TT (n = 15-20) |
P-value | |
|---|---|---|---|
| Age (yr) | 57 ± 1 | 58 ± 1 | 0.684 |
| HRT use (yes/no) | 22/16 | 6/14 | ------ |
| VO2max (mLkg-1min-1) | 23.1 ± 0.5 | 23.3 ± 0.7 | 0.816 |
| Weight (kg) | 73.8 ± 2.0 | 76.0 ± 2.8 | 0.531 |
| BMI (kgm-2) | 27.7 ± 0.7 | 27.9 ± 1.0 | 0.868 |
| Fat free mass (kg) | 38.9 ± 0.9 | 40.1 ± 1.2 | 0.443 |
| IA fat (cm2) | 110 (100-121) | 111 (97-127) | 0.880 |
| SC fat (cm2) | 347 ± 19 | 374 ± 26 | 0.420 |
| Total fat (%) | 42.0 ± 1.1 | 42.7 ± 1.5 | 0.745 |
| Glucose (mmolL-1) | 4.8 ± 0.1 | 5.1 ± 0.1 | 0.079 |
| Insulin (pmolL-1) | 76 ± 5 | 77 ± 6 | 0.953 |
| ISI | 3.7 (3.1-4.4) | 3.3 (2.6-4.1) | 0.373 |
| Glucose AUC (mmolL-1 × min) | 857 ± 39 | 965 ± 49 | 0.100 |
| Insulin AUC (pmolL-1 × min) | 45499 (37844-54702) | 48753 (38726-61376) | 0.644 |
Data are expressed as adjusted means ± SE with the exception of intra-abdominal fat, ISI, and insulin AUC, which are presented as the back transformed mean of the log transform (95 % confidence interval). HRT, hormone replacement therapy; VO2max, maximal oxygen consumption; BMI, body mass index; IA; intra-abdominal; SC, subcutaneous; ISI, insulin sensitivity index; AUC, total area under the curve; n, sample size. Sample sizes are varied due to the inability to obtain all measurements on all participants. P-value is for the main effect of genotype.
*
indicates significant difference between genotype groups p ≤ 0.05.