Table 1.
Comparison of vertebrate MOR, DOR, and KOR protein sequences within vertebrate species and by group
| Group/Species | MOR vs. DOR | MOR vs. KOR | DOR vs. KOR | Species mean (S.E.M.)a | Group mean (S.E.M.) |
|---|---|---|---|---|---|
| Percent amino acid identity | |||||
| Non-mammals | |||||
| Danio rerio | 70 | 62 | 65 | 65.7 (2.3) | |
| Rana pipiens | 73 | 65 | 63 | 67.0 (3.1) | |
| Taricha granulose | 70 | 66 | 68 | 68.0 (1.2) | 66.9 (1.2)† |
| Mammals | |||||
| Rattus norvegicus | 66 | 61 | 61 | 62.7 (1.7) | |
| Mus musculus | 61 | 60 | 61 | 60.7 (0.3) | |
| Homo sapiens | 62 | 60 | 59 | 60.3 (0.9) | 61.2 (0.7) |
| Percent amino acid similarity | |||||
| Non-mammals | |||||
| Danio rerio | 82 | 79 | 79 | 80.0 (1.0)* | |
| Rana pipiens | 85 | 81 | 77 | 81.0 (2.3)* | |
| Taricha granulose | 82 | 80 | 82 | 81.3 (0.7)* | 80.8 (0.7)† |
| Mammals | |||||
| Rattus norvegicus | 77 | 75 | 75 | 75.6 (0.7) | |
| Mus musculus | 72 | 75 | 74 | 73.6 (0.9) | |
| Homo sapiens | 73 | 74 | 72 | 73.0 (0.6) | 74.1 (0.5) |
Ver. BLASTP 2.2.14, settings: matrix: Blossum62, gap open: 11, gap extension: 1, x-drop-off: 50, expect: 10.00, wordsize: 3, and filter off.
a
Standard error of the mean.
*
Denotes significantly different % similarity than rat, mouse, and human mean values (p < 0.05, one-way ANOVA followed by post-hoc Newman–Kuels test).
†
Denotes group means (N = 9) different for identity and similarity at p < 0.01, Student’s t-test.