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Dynamin is necessary for PDGF-induced lamellipodia. (A-I) Rat1 fibroblasts overexpressing dynamin-2 constructs were plated on FN-coated coverslips, serum-starved for 16 h, stimulated with PDGF (20 ng/ml) for 30 min and stained for overexpressed dynamins (anti-HA) and filamentous actin (rhodamine-phallodin). (J) Lamellipodial extent was quantified as fraction of cell circumference on 20 randomly selected cells in each group. Bar, 10 μm; mean ± SEM; *p < 0.001.
