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Membrane-bound Rac is internalized with macropinosomes. NIH3T3 cells were microinjected with plasmids encoding GFP-V12Rac or GFP-Rac(WT), incubated for 90 min, exposed to rhodamine-labeled 70-kDa dextran (0.5 mg/ml) for 30 min, fixed, mounted, and subjected to confocal microscopy. (B-D) Close-up as indicated in A. (F-H) Close-up as indicated in E. (B and F) Rhodamine-dextran indicating pinosomes. (C) GFP-V12Rac. (G) GFP-Rac(WT). (A, D, E, and H) Merged images. Bars, 10 μm.
