Table 1.

The Effects of GLP-1 Infusion on Hemodynamics in Dogs with Dilated Cardiomyopathy (DCM)

DCM + Vehicle				DCM +GLP-1

	Baseline	DCM28 days	DCM30 days	Baseline	DCM28 days	DCM30 days	p Value for Interaction
LV Pressure(mmHg)	121±6	103±2	104±3	126±6	105±3	114±4	0.20
LV End Diastolic Pressure(mmHg)	8±1	32±4	30±4	9±2	32±3	20±2^*	0.001
LV dP/dt(mmHg)	2887±198	1542±106	1602±124	2980±241	1378±211	2150±210^*	0.010
Heart Rate(min⁻¹)	80±6	121±9	108±9	84±4	115±8	89±5^*	0.001
Mean Arterial Pressure(mmHg)	92±8	86±4	85±3	96±4	86±5	83±4	0.44
Cardiac Output(l/min)	2.3±0.1	1.5±0.1	1.7±0.2	2.4±0.2	1.6±0.1	2.1±0.2^*	0.007
Coronary Blood Flow(ml/min)	21±3	30±2	30±4	22±4	32±3	35±4	0.50
LV Ejection Fraction (%)	49±4	22±3	22±4	51±4	20±4	39±3^*	0.002
MVO₂ mlO₂/min	215±13	318±38	320±43	200±9	307±26	324±38	0.93

significant difference in response to DCM+GLP-1 compared to DCM+vehicle