Table 2.
DCM+Vehicle (n=6) | DCM+GLP-1 (n=9) | ||||||
---|---|---|---|---|---|---|---|
Baseline | DCM28 days | DCM30 days | Baseline | DCM28 days | DCM30 days | p Value for Interaction | |
Plasma Glucose mmol/l | 5.6±0.2 | 5.5±0.2 | 5.4±0.2 | 5.3±0.3 | 5.4±0.4 | 5.2±0.2 | 0.74 |
Plasma NEFAμmo/l | 598±54 | 623±67 | 676±104 | 643±91 | 553±76 | 648±45 | 0.89 |
Plasma Insulin pmol/l | 38±8 | 114±20 | 80±9 | 56±8 | 99±16 | 58±9* | 0.007 |
Plasma Glucagon pg/ml | 23±5 | 39±6 | 41±4 | 29±2 | 47±6 | 31±3* | 0.03 |
Arterial NO μM | 15.9±1.1 | 11.8±1.0 | 12.2±0.9 | 16.7±1.1 | 10.8±1.0 | 17.3±1.0* | 0.04 |
Plasma NE nmol/l | 0.47±0.04 | 1.21±0.1 | 1.07±0.12 | 0.39±0.09 | 1.17±0.1 | 0.81±0.09* | 0.03 |
Glucose Clamp | |||||||
Basal(μmol/min/g) | 1.1±0.4 | 1.8±0.5 | 2.1±0.6 | 0.9±0.4 | 1.9±0.7 | 5.8±1.1* | 0.002 |
Hyperinsulinema(μmol/min/g) | 15±3 | 7±3 | 7±3 | 14±3 | 6±3 | 21±4* | 0.0001 |
significant difference in response DCM+GLP-1 compared to DCM+vehicle