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Time course of the analgesic effects of morphine, chlorpromazine, diphenhydramine, and buprenorphine following systemic administration in amphibians (n = 4 to 6 animals per group). ●, morphine (300 nmol/g); ▽, chlorpromazine (30 nmol/g); ■, diphenhydramine (200 nmol/g); ⋄, haloperidol (30 nmol/g). [“Key” deleted from illustration] Saline-injected control group did not give a significant effect and is omitted for clarity.
