. Author manuscript; available in PMC: 2011 Apr 13.

Published in final edited form as: Contemp Top Lab Anim Sci. 2001 Jul;40(4):23–27.

Table 2.

Lethality data for the tested agents after subcutaneous administration in Rana pipiens

Agent	Class	Tested dose (nmol/g)	Lethality^a
Buprenorphine	Partial opioid agonist	100	3/4
Butorphanol	Partial opioid agonist	300	4/4
Diphenhydramine	HI antagonist	250	4/4
Chlorpromazine	Antipsychotic	1000	5/6
Haloperidol	Antipsychotic	Not done^b	Not determined^b
Chlordiazepoxide	Benzodiazepine	1000	3/6
Pentobarbital	Barbiturate	100	3/6
Ketorolac	NSAID	1000	1/4
Indomethacin	NSAID	Not done^b	Not determined^b

NSAID, non-steroidal anti-inflammatory’ drug

Number of animals dead within 24 h/total number of animals tested at that dose.

Higher doses not tested, because of insolubility of drug into vehicle at the higher concentration.