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Type I interferon (IFN) regulates CD4+ T helper cell development. IFN-α/β contributes to various functions of T helper type 1 (Th1) cells, particularly the secretion of interleukin-2 (IL-2) by memory cells. Conversely, IFN-α/β restricts the development of alternative populations such as Th2 and Th17. pDCs, plasmacytoid dendritic cells; TLR, toll-like receptor.
