Table 3.

Tissue- and cell-specific expression of EGFP-Rab27a

Tissue / organ	Cell type	Intracellular distribution	Regulated secretion
Stomach	Parietal cells	Perinuclear	Yes
	Chief cells	Surface of zymogen granules	Yes
	Mucous-secreting cells	Apical region	Yes
	Neck mucous cells	Surface of mucigen granules
	Enteroendocrine cells	Basal position	Yes
Small intestine	Paneth cells	Surface of apical granules	Yes
	Goblet cells	Surface of mucigen granules	Yes
	Enteroendocrine cells	Basal position	Yes
Large intestine	Goblet cells	Surface of mucigen granules, plasma membrane, dense granules	Yes
Pancreas	Pancreatic acinar cells	Surface of zymogen granules	Yes
	Islet alpha cells	Subplasmalemmal	Yes
	Islet beta cells	Diffuse	Yes
Lung	Pneumocytes type II	Diffuse	Yes
	Clara cells	Subplasmalemmal	Yes
Hyaline cartilage	Chondrocytes	Subplasmalemmal	Yes
Ovary	Oocyte	Diffuse	Yes
	Granulosa lutein cells	Diffuse
Uterus	Epithelium of endometrium	Apical region	Yes
	Myometrium
Skin	Basal keratinocytes	Subplasmalemmal
	Melanocytesa
Sebaceous gland	Sebum-producing acinar cell		Yes
Adrenal gland	Zona reticularis cells	Diffuse	Yes
	Adrenaline-secreting cells	Diffuse	Yes
Thyroid gland	Follicular cells	Apical localisation	Yes
Submandibular gland	Serous secretory cells	Surface of zymogen granules	Yes
	Mucous secretory cells	Surface of mucigen granules	Yes
	Striated ducts epithelium	Apical localisation	Yes
	Myoepithelial cells
Spleen	Neutrophilsb	Diffuse	Yes
Lymph node	T-cells	Surface of lytic granules	Yes
Thymus	B-cellsb		Yes
Bone marrow	Eosinophilsb	Diffuse	Yes
Blood	Basophilsb	Diffuse	Yes
	Mast cellsb	Basophilic granules	Yes

^aFunctional rather than morphological evidence (see Figure 3)

^bBarral and Seabra (unpublished data)