Effect of aging and genotype on the survival rate (A), aneurismal ascending aorta of 24-month-old Fbn1+/mgΔ mouse (B) (the arrow indicate the saccular aneurysm at the vessel root), and histological examination of semi-thin sections of ascending aorta of 3-week-old, 6- and 24-month-old mice (C). Eosin/Hematoxylin staining of cross-sections of ascending aorta of Fbn1+/+, non-pathological Fbn1+/mgΔ, and pathological Fbn1+/mgΔ (Patho) 24-month-old mice (D). n=45 for (A). Bar sizes: 1mm (B) and 500μm (D).