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Classifying the regions of the FNR design space. (A) Dividing the design space into aerobic-like, microaerobic-like, or anaerobic-like behaviors based on the underlying subsystems (see main text for details), which gives rise to low (aerobic-like regions), medium (microaerobic-like regions), or high (anaerobic-like) levels of the active FNR protein. (B) Dividing the design space into aerobic, microaerobic, or anaerobic environments based on the dissolved O2 content.
