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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Cancer Res. 2011 Jan 1;71(1):40–50. doi: 10.1158/0008-5472.CAN-10-2004

Figure 6. Role of Foxm1 in the cross-talk between endothelial and epithelial cells during lung tumorigenesis.

Figure 6

After Foxm1 deletion from endothelial cells, expression of Flk-1, Foxf1 and Sfrp1 is decreased. These endothelial genes are direct Foxm1 targets. Decreased Flk-1 and Foxf1 expression promotes chronic lung inflammation in enFoxm1−/− lungs. Decreased Sfrp1 and Foxf1 expression causes activation of canonical Wnt signaling in respiratory epithelium. Chronic lung inflammation and Wnt-induced epithelial proliferation promote lung tumorigenesis in enFoxm1−/− mice.