Table 4.
Odds Ratios for CKD Awareness, KEEP Participants With Reclassified Versus Unchanged CKD Stage
| CKD Stage Reclassification from MDRD Study to CKD-EPI eGFR | Unadjusted OR (95% CI) | Adjusted OR (95% CI)a |
|---|---|---|
| Full analytic cohort, n = 23,572 | ||
| Reclassified as less advanced | 0.58 (0.51-0.66) | 0.58 (0.50-0.67) |
| Unchanged | 1.00 (Reference) | 1.00 (Reference) |
| Reclassified as more advanced | 1.48 (1.05-2.10) | 1.50 (1.05-2.13) |
| MDRD Study Stage 1-2 CKD, n = 8134 | ||
| Reclassified as less advanced | 0.99 (0.74-1.33) | 0.92 (0.68-1.23) |
| Unchanged | 1.00 (Reference) | 1.00 (Reference) |
| Reclassified as more advanced | 0.96 (0.47-1.96) | 1.13 (0.54-2.38) |
| MDRD Study Stage 3 CKD, n = 14,456 | ||
| Reclassified as less advanced | 0.54 (0.45-0.63) | 0.45 (0.38-0.54) |
| Unchanged | 1.00 (Reference) | 1.00 (Reference) |
| Reclassified as more advanced | 2.16 (1.34-3.49) | 2.56 (1.56-4.19) |
| MDRD Study Stage 4-5 CKD, n = 982 | ||
| Reclassified as less advanced | 0.83 (0.47-1.46) | 0.56 (0.30-1.04) |
| Unchanged | 1.00 (Reference) | 1.00 (Reference) |
| Reclassified as more advanced | 2.28 (0.76-6.85) | 3.38 (1.05-10.83) |
Note: CKD stages are defined as follows: Stage 1, eGFR ≥ 90 mL/min/1.73 m2 with ACR ≥ 30 mg/g; Stage 2, eGFR 60-89 mL/min/1.73 m2 with ≥ ACR 30 mg/g; Stage 3, eGFR 30-59 mL/min/1.73 m2; Stages 4-5, eGFR < 30 mL/min/1.73 m2.
ACR, albumin-creatinine ratio; CI, confidence interval; CKD, chronic kidney disease; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; OR, odds ratio.
a
Adjusted for age, sex, race, education, insurance, diabetes, hypertension, cardiovascular disease, and screening year.