Figure 2.

Fos immunoreactivity after swim stress and acute cocaine administration. Example photomicrographs demonstrating that wild-type mice exhibit an increase in Fos protein expression within the vBNST (b, d) and IL (g, i) after forced swim stress or acute cocaine administration. CREBαΔ mutant mice do not show stress-induced increases in Fos protein expression within the vBNST (c), whereas expression within the IL remains intact (h). No differences are seen in the response to acute cocaine in CREBαΔ mutant mice (e, j) FST, Forced swim test.