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Naive CREB mutant mice exhibit a decrease in immobility during swim stress compared with wild-type littermates; however, conditioned place preference-experienced animals do not. Throughout the forced swim test in experiment I (a), mutant mice exhibited lower levels of immobility than their wild-type littermates. However, in experiment II (b), no differences were seen between the genotypes. *p < 0.05, **p < 0.01, ***p < 0.001 compared with wild type.
