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. Author manuscript; available in PMC: 2012 Apr 13.
Published in final edited form as: Structure. 2011 Apr 13;19(4):546–554. doi: 10.1016/j.str.2011.01.016

Figure 2.

Figure 2

HX MS of the Notch1 NRR in the “off” state. (A) Extent of deuteration of peptides from the Notch1 NRR. The relative percent deuteration is colored based on a sliding scale from yellow (<10% incorporation) to deep red (>60% incorporation). Portions of the protein for which it was not possible to acquire exchange information are colored gray. (B) HX MS results comparing exchange of precursor and S1 cleaved forms of the Notch1 NRR. There were no detectable differences in the rates of peptide deuteration between the two proteins (see Supplemental Figure 3 for exchange curves). An absolute difference in mass of less than 0.5 Da is reported as “no change”. See also Figures S2 and S3, Table S1 and Movie S1.

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