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. 2011 Feb 7;286(15):12860–12869. doi: 10.1074/jbc.M110.191098

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Amino acid substitutions identified in 3 selected random mutants of the cricket Δ12/Δ9-desaturase. A, proposed topology model of the cricket acyl-CoA Δ12/Δ9 fatty acid desaturase. The positions of selected random mutations are indicated by black circles. ER lumen, endoplasmic reticulum lumen. B, partial ClustalW alignment of the cricket Δ9-desaturase (AdD9des), cricket Δ12/Δ9-desaturase (AdD12/9des), and cricket Δ12/Δ9-desaturase mutants 1.1, 2.1, 2.2 and 2.3. Identical residues are shaded, conserved histidine clusters 1 and 2 are underlined, and asterisks below the alignment indicate selected random mutations.