FIGURE 6.

Effect of sorafenib and PLX4720 on the rate of recovery from an acute acid load in malignant melanoma cell lines. A, cells were treated with 10 μm sorafenib for 20 min prior to assay, and an acute acid load was induced in cell lines in the presence or absence of 10 μm sorafenib. The rate of recovery from the acid load in the presence of sorafenib was compared with that in its absence. B, as in A but with 5 μm PLX4720. Results are mean ± S.E. of 6–8 experiments. * indicates significantly different from the rate of recovery in the absence of sorafenib or PLX4720 at p < 0.01.