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Defective ceramide and sphingoid base formation in Niemann-Pick dermal fibroblasts. Sphingolipids were measured in control, NPD-1, and NPD-2 fibroblasts following treatment with vehicle (PBS) or TNF-α (20 ng/ml) for 18 h. A, total sphingomyelin; B, total ceramide; C, sphingosine; and D, sphingosine 1-phosphate (n = 4; two-way ANOVA with Bonferroni post-test, *, p < 0.05 versus Ctl cells).
