FIGURE 1.
A, genomic location of copA, copZ, and the predicted csoR in S. aureus Newman. The DNA sequence in the copA promoter region is also shown compared with the Bsu copZA operator, which has been shown to be regulated and bound tightly by Bsu CsoR (15, 20). B, analysis of copA transcription by RT-PCR in WT and ΔcsoR grown in the absence or presence of 1.0 mm CuCl2 (Cu) or MnCl2 (Mn) as indicated. The results are the average of four independent experiments. *, p < 0.05 determined by Student's t test. Error bars = S.D.