TABLE 3.
Kinetic parameters of anti-VEGF peptide antibodies binding to rhVEGF
Results were obtained from surface plasmon resonance assay where binding of anti-peptide antibodies to immobilized rhVEGF on the chip was observed at different concentrations.
| Antibody | ka (1/ms) × 103 | kd (1/s) × 10−3 | KD |
|---|---|---|---|
| nm | |||
| Anti-VEGF(102–122) | 6.2 | 3.6 | 552 |
| Anti-VEGF-P3(NC) | 6.7 | 1.4 | 251 |
| Anti-VEGF-P3(CYC) | 8.6 | 1.3 | 146 |
| Anti-mAb VEGF | 86.1 | 2.7 | 29 |