Table 2. 5-HT (10 mmol/liter) induced contractions of isolated guinea pig ileum.
| Compound | Dose, mmol/dl | Contraction rate, % |
|---|---|---|
| Before | 100 | |
| Vehicle† | 105 ± 2 | |
| l-Lysine | 0.007 | 109 ± 4 |
| 0.07 | 90 ± 3* | |
| 0.7 | 75 ± 5** | |
| l-Leucine | 0.07 | 103 ± 5 |
| 0.7 | 98 ± 6 |
Data are means ± SEM of three animals. *, P < 0.05; and **, P < 0.01 (significant difference from vehicle).
Distilled water (100 μl/10 ml).