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. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: Clin Cancer Res. 2011 Feb 15;17(4):654–666. doi: 10.1158/1078-0432.CCR-10-2634

Figure 2. Role of autophagy in suppressing liver damage and cell death.

Figure 2

(A) Elevated p62, ubiquitin and accumulation of lipids in aged beclin1+/− mouse liver. Sections of liver from young (16 months old) and aged (> 24 months old) beclin1 +/+ and +/− mice and a representative spontaneous liver tumor from a beclin1+/− mouse were stained with H&E, and by immunohistochemistry for p62 and ubiquitin, and with BODIPY to indicate lipid droplet accumulation by fluorescence. (B) Autophagy promotes cell viability in metabolic stress. Representative images of immortal baby mouse kidney epithelial (iBMK) cells derived from atg7+/+ and −/− mice that were untreated, treated with metabolic stress (ischemia: no glucose and 1% oxygen or hypoxic conditions) and allowed to recover (35). Images generously provided by Dr. C. Karp and H.-Y. Chen from the White laboratory.