A: qRT-PCR of middle ear cytokines comparing acute and chronic OM. Chronic OM caused greater expression of IL-1α and IL-1β, while most other cytokines were similar in their expression in the two OM models. See Tables 1A and 2A for significant probability values.
B: qRT-PCR of inner ear cytokines comparing acute and chronic OM. Several of the cytokine genes were expressed in greater amounts in the chronic condition. The interleukins in particular were significantly higher in the cochlea with the long standing infection. See Tables 2A and 2B for significant probability values.