Figure 8.

Noradrenergic modulation of subthreshold properties of mPFC neurons. Bath application of the α2-adrenergic agonist clonidine (Clon; 100 μm) differentially effects CPn and COM neurons. A–G, Effects of clonidine on steady-state input resistance (A–C), sag ratio (D), and membrane time constant (E–G). H, I, Clonidine shifts the ZAP of CPn but not COM neurons, making CPn neurons drop in resonance frequency. J, αEPSPs were injected with current such that they depolarized the neurons from −65 to −55 mV. With the addition of clonidine, only CPn neurons are driven to fire an action potential. K, Reducing the current injection to span from −65 to −55 mV in the presence of clonidine reveals an increase in CPn but not COM EPSP ratio. *p < 0.05.