Table 2.

Adult neurogenesis during disease.

Disease	Area	Rodent data	Human data
Epilepsy	Hippo.	Acute increase in proliferation	Increase in pNPCs and proliferation in pediatric patients
		Acute increase in neurogenesis	Increase or no change in proliferation in adult patients
		Aberrant and ectopic new neurons Chronic depletion	Decrease, no changed or increase in pNBs in adult patients
Huntington's disease	SVZ	Increased or unchanged SVZ proliferation migration of new neurons into the striatum	Increase in proliferation; thicker SVZ increase in pNPCs and pNBs
Alzheimer's disease	SVZ	Decrease in proliferation Decrease in differentiation	Decrease in proliferation Increase in pNPCs
	Hippo.	Increase, no change or decrease in proliferation Increase in neurogenesis Decrease in differentiation and survival of newborn neurons	No change in proliferation Increase in pNBs
Parkinson's disease	SVZ	Decrease in proliferation Transient decrease in OB neurogenesis Increase in OB neurogenesis and total neurons	Decrease in proliferation Decrease in putative OB progenitors Increase in OB neurogenesis and DA neurons
	Hippo.	Decrease in proliferation No proliferation or NPCs	Decrease in pNPCs
	S. nigra	Induction of neurogenesis	No proliferation or pNPCs
Stroke	SVZ	Increase in proliferation Increase in neurogenesis	NR
	Hippo.	Increase in proliferation Increase in neurogenesis	NR
	Striatum	Induction of neurogenesis from SVZ progenitors	NR
	Cortex	Induction of neurogenesis from SVZ progenitors	Increase in proliferation Increase in pNBs
Depression	Hippo.	Antidepressants increase proliferation and neurogenesis	Increase or no changes in proliferation
			Increase in pNPCs in patients treated with antidepressants

This table summarizes the major changes in neurogenesis in human neurological and psychiatric disorders. For details and references, see main text.

Hippo., hippocampus; S. nigra, substantia nigra; NR, non-reported.