Table 1.
Landscape of Somatic Alterations in Primary Human Prostate Cancers
| PR-0508 | PR-0581* | PR-1701* | PR-1783 | PR-2832* | PR-3027 | PR-3043 | |
|---|---|---|---|---|---|---|---|
| Tumor Bases Sequenced | 97.8 × 109 | 93.9 × 109 | 110 × 109 | 90.9 × 109 | 106 × 109 | 93.6 × 109 | 94.9 × 109 |
| Normal Bases Sequenced | 96.7 × 109 | 57.8 × 109 | 108 × 109 | 92.3 × 109 | 103 × 109 | 87.8 × 109 | 96.6 × 109 |
| Tumor Haploid Coverage | 31.8 | 30.5 | 35.8 | 29.5 | 34.4 | 30.4 | 30.8 |
| Normal Haploid Coverage | 31.4 | 18.8 | 34.9 | 30.0 | 33.4 | 28.5 | 31.4 |
| Callable Fraction | 0.84 | 0.83 | 0.87 | 0.82 | 0.84 | 0.84 | 0.85 |
| Estimated Tumor Purity** | 0.73 | 0.60 | 0.49 | 0.75 | 0.59 | 0.74 | 0.68 |
| All Point Mutations (high confidence) | 3898 (1447) | 3829 (1430) | 3866 (1936) | 4503 (2227) | 3465 (1831) | 5865 (2452) | 3192 (1713) |
| Nonsilent Coding Mutations (high confidence) | 16 (5) | 20 (3) | 24 (9) | 32 (20) | 13 (7) | 43 (16) | 14 (10) |
| Mutation Rate | 0.7 per Mb | 0.7 per Mb | 0.8 per Mb | 1.0 per Mb | 0.8 per Mb | 1.2 per Mb | 0.7 per Mb |
| Rearrangements | 53 | 67 | 90 | 213 | 133 | 156 | 43 |
*
harbors TMPRSS2-ERG gene fusion
**
estimated from SNP array-derived allele specific copy number levels using the ABSOLUTE algorithm (see Supplementary Methods).