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. 2011 Feb 15;6:363–371. doi: 10.2147/IJN.S15881

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© 2011 Eskandari et al, publisher and licensee Dove Medical Press Ltd.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

PMC Copyright notice

Comparison between the effect of sodium valproate solution positive control (150 mg/kg), NLCs of VPA (20 mg/kg), and control NLCs (without VPA) in IP route of administration on MES seizure protection which was assessed as the decrease of extension:flexion (E:F) ratio (n = 6).

Notes: *Statistically significant difference (P < 0.05) with respect to the control (empty) NLC group according to one-way ANOVA and Tukey test; ^¥Statistically significant difference (P < 0.05) with respect to the positive control group according to 1-way ANOVA and Tukey test.

Abbreviations: E:F ratio, extension:flexion ratio; VPA, valproic acid; NLCs, nanostructured lipid carriers; MES, maximal electroshock; IP, intraperitoneal.