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Proposed Classification System for Sequence Variants Identified by Genetic Testing
| Class | Description | Probability of being Pathogenic |
|---|---|---|
| 5 | Definitely Pathogenic | >0.99 |
| 4 | Likely Pathogenic | 0.95–0.99 |
| 3 | Uncertain | 0.05–0.949 |
| 2 | Likely Not Pathogenic or of Little Clinical Significance | 0.001–0.049 |
| 1 | Not Pathogenic or of No Clinical Significance | <0.001 |
