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. Author manuscript; available in PMC: 2011 Apr 13.
Published in final edited form as: Open Parasitol J. 2010;4:72–76. doi: 10.2174/1874421401004010072

Fig. 1. ECM interactome of early Trypanosoma cruzi infection.

Fig. 1

The network was connected by using Laminin gamma-1 (LAMC1), Thrombospondin-1 (THBS1), and Galectin-3 (LGALS3) as initial seed nodes (large DIAMOND nodes). Node expansion was done to one degree of biological protein-protein interaction partners of the seed nodes using the Michigan Molecular Interaction Database. Proteins mapping to the canonical “ECM- Receptor Interaction Pathway” of KEGG (hsa04512) are highlighted as following: GREEN nodes are ECM ligands: (laminins, collagens, fibronectin, heperan sulfate, and thrombospondin-1). RED nodes are ECM receptors: (integrins, cd35, cd47, and SV2A). BLUE nodes are not part of the KEGG ECM-ECM Receptor Pathway, but have established biological interactions with ECM-Receptor interaction nodes.